Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC067
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-07 12:12
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl PK mertz a 100mg 2+1+0 tbl Oprymea a 1,05mg jedna ujutru Old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 34, 'TN': 25, 'TP': 8, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 23, 'TN': 17, 'TP': 19, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 26, 'TN': 21, 'TP': 16, 'FP': 9}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 10, 'TN': 7, 'TP': 32, 'FP': 23}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 16.78
timePerCircleCoV 0.173547
timePerCircleSlope 0.000447864
meanError 1.48225
tremorFreq 6.34766
tremorRelPower 25.3892
tremorGyroAmpMean 0.0134105
tremorGyroAmpSlope 0.00121846
tremorGyroAmpCoV 0.423313
tremorCoordAmpMean 0.0261017
tremorCoordAmpSlope -7.41697e-05
tremorCoordAmpCoV 0.309572
tremorAccAmpMean 0.0462269
tremorAccAmpSlope -0.000130527
tremorAccAmpCoV 0.0910988
tremorPcRelVar 0.58429
tremorPcX -0.898237
tremorPcY 0.439511

Circle Segment 1

Duration 20.08 s, Accuracy Estimate 1.789 (lower is better)

Circle Segment 2

Duration 15.72 s, Accuracy Estimate 1.294 (lower is better)

Circle Segment 3

Duration 11.2 s, Accuracy Estimate 1.454 (lower is better)

Circle Segment 4

Duration 18.84 s, Accuracy Estimate 1.329 (lower is better)

Circle Segment 5

Duration 17.16 s, Accuracy Estimate 1.189 (lower is better)

Circle Segment 6

Duration 19.88 s, Accuracy Estimate 1.733 (lower is better)

Circle Segment 7

Duration 15.12 s, Accuracy Estimate 1.266 (lower is better)

Circle Segment 8

Duration 13.44 s, Accuracy Estimate 1.226 (lower is better)

Circle Segment 9

Duration 19.0 s, Accuracy Estimate 1.479 (lower is better)

Circle Segment 10

Duration 17.36 s, Accuracy Estimate 2.062 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 51.864
timePerSpiralCoV 0.161654
timePerSpiralSlope -0.0456579
meanError 1.97597
tremorFreq 6.25
tremorRelPower 23.0109
tremorGyroAmpMean 0.0135702
tremorGyroAmpSlope -0.00019098
tremorGyroAmpCoV 0.389375
tremorCoordAmpMean 0.0252056
tremorCoordAmpSlope 0.000699485
tremorCoordAmpCoV 0.274222
tremorAccAmpMean 0.0727398
tremorAccAmpSlope 8.63919e-05
tremorAccAmpCoV 0.0326349
tremorPcRelVar 0.598606
tremorPcX -0.810276
tremorPcY -0.586048

Spiral Segment 1

Duration 65.16 s, Accuracy Estimate 1.89 (lower is better)

Spiral Segment 2

Duration 46.48 s, Accuracy Estimate 1.705 (lower is better)

Spiral Segment 3

Duration 49.08 s, Accuracy Estimate 2.298 (lower is better)

Spiral Segment 4

Duration 44.08 s, Accuracy Estimate 2.054 (lower is better)

Spiral Segment 5

Duration 54.52 s, Accuracy Estimate 1.933 (lower is better)

Elel

eDurationMean 0.626622
eDurationStd 0.0992196
eDurationStdnorm 0.15834
eDurationMedian 0.635
eDurationQuartdelta 0.12125
eDurationQuartdeltanorm 0.190945
eDurationKurt 3.30095
eDurationTrenddiff 0.01
eDurationTrendratio 1.01581
eWidthMean 2.65622
eWidthStd 0.773078
eWidthStdnorm 0.291045
eWidthMedian 2.457
eWidthQuartdelta 1.17
eWidthQuartdeltanorm 0.47619
eWidthKurt 2.5276
eWidthTrenddiff -0.4095
eWidthTrendratio 0.851064
eHeightMean 7.73465
eHeightStd 1.45736
eHeightStdnorm 0.18842
eHeightMedian 7.605
eHeightQuartdelta 1.55025
eHeightQuartdeltanorm 0.203846
eHeightKurt 2.53707
eHeightTrenddiff -0.117
eHeightTrendratio 0.984733
eAspectMean 0.344373
eAspectStd 0.0761445
eAspectStdnorm 0.22111
eAspectMedian 0.343284
eAspectQuartdelta 0.113413
eAspectQuartdeltanorm 0.330378
eAspectKurt 2.84648
eAspectTrenddiff 0.000864577
eAspectTrendratio 1.00253
eSlantMean -0.307244
eSlantStd 0.156325
eSlantStdnorm -0.508798
eSlantMedian -0.322581
eSlantQuartdelta 0.171596
eSlantQuartdeltanorm -0.531948
eSlantKurt 2.51595
eSlantTrenddiff 0.0110627
eRtopMean 0.538822
eRtopStd 0.140828
eRtopStdnorm 0.261362
eRtopMedian 0.571429
eRtopQuartdelta 0.199131
eRtopQuartdeltanorm 0.348479
eRtopKurt 2.72644
eRtopTrenddiff 0.0208042
eRbotMean 1.5004
eRbotStd 0.45134
eRbotStdnorm 0.300813
eRbotMedian 1.58824
eRbotQuartdelta 0.669643
eRbotQuartdeltanorm 0.421627
eRbotKurt 2.35943
eRbotTrenddiff -0.116966
eRrightMean 0.751249
eRrightStd 0.126756
eRrightStdnorm 0.168727
eRrightMedian 0.769231
eRrightQuartdelta 0.16004
eRrightQuartdeltanorm 0.208052
eRrightKurt 3.75185
eRrightTrenddiff 0.0342312
eRleftMean 0.591364
eRleftStd 0.0878989
eRleftStdnorm 0.148638
eRleftMedian 0.590909
eRleftQuartdelta 0.124664
eRleftQuartdeltanorm 0.210969
eRleftKurt 2.34961
eRleftTrenddiff -0.0534069
lDurationMean 0.751625
lDurationStd 0.124774
lDurationStdnorm 0.166005
lDurationMedian 0.7475
lDurationQuartdelta 0.1325
lDurationQuartdeltanorm 0.177258
lDurationKurt 3.87983
lDurationTrenddiff -0.11
lDurationTrendratio 0.8625
lWidthMean 2.62957
lWidthStd 0.459666
lWidthStdnorm 0.174806
lWidthMedian 2.691
lWidthQuartdelta 0.585
lWidthQuartdeltanorm 0.217391
lWidthKurt 3.77044
lWidthTrenddiff -0.234
lWidthTrendratio 0.913043
lHeightMean 13.1742
lHeightStd 1.14077
lHeightStdnorm 0.0865916
lHeightMedian 13.221
lHeightQuartdelta 1.9305
lHeightQuartdeltanorm 0.146018
lHeightKurt 1.97343
lHeightTrenddiff -0.7605
lHeightTrendratio 0.943723
lAspectMean 0.201628
lAspectStd 0.0439097
lAspectStdnorm 0.217776
lAspectMedian 0.198344
lAspectQuartdelta 0.0507194
lAspectQuartdeltanorm 0.255714
lAspectKurt 4.1711
lAspectTrenddiff -0.00851564
lAspectTrendratio 0.957425
lSlantMean -0.210211
lSlantStd 0.0722954
lSlantStdnorm -0.343919
lSlantMedian -0.210733
lSlantQuartdelta 0.104274
lSlantQuartdeltanorm -0.494814
lSlantKurt 2.84502
lSlantTrenddiff 0.0662511
lRtopMean 0.46825
lRtopStd 0.13377
lRtopStdnorm 0.285681
lRtopMedian 0.45
lRtopQuartdelta 0.169474
lRtopQuartdeltanorm 0.376608
lRtopKurt 3.90594
lRtopTrenddiff 0.0126374
lRbotMean 1.57268
lRbotStd 0.443556
lRbotStdnorm 0.282038
lRbotMedian 1.6
lRbotQuartdelta 0.365633
lRbotQuartdeltanorm 0.22852
lRbotKurt 12.9834
lRbotTrenddiff -0.163587
lRrightMean 0.76003
lRrightStd 0.0795216
lRrightStdnorm 0.10463
lRrightMedian 0.770274
lRrightQuartdelta 0.0996376
lRrightQuartdeltanorm 0.129353
lRrightKurt 2.56295
lRrightTrenddiff -0.00965543
lRleftMean 0.633196
lRleftStd 0.104837
lRleftStdnorm 0.165568
lRleftMedian 0.640278
lRleftQuartdelta 0.133865
lRleftQuartdeltanorm 0.209073
lRleftKurt 2.75366
lRleftTrenddiff -0.105772

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 1
sumTouchScores 23
meanMovementTime 0.795909
numTouches 23
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.908865
sumTouchScores 15.4507
meanMovementTime 1.00625
numTouches 17
undershootPercentage 0
overshootPercentage 11.7647

ZigZag

numZigzags 5
timePerZigzagMean 32.984
timePerZigzagCoV 0.0500645
timePerZigzagSlope 0.00642736
meanError 1.92771
tremorFreq 6.15234
tremorRelPower 21.9264
tremorGyroAmpMean 0.0212007
tremorGyroAmpSlope -0.00149207
tremorGyroAmpCoV 0.343154
tremorCoordAmpMean 0.044145
tremorCoordAmpSlope -0.00136523
tremorCoordAmpCoV 0.30381
tremorAccAmpMean 0.0740167
tremorAccAmpSlope -0.000181046
tremorAccAmpCoV 0.103711
tremorPcRelVar 0.605072
tremorPcX 0.181281
tremorPcY 0.983431

ZigZag Segment 1

Duration 34.4 s, Accuracy Estimate 2.091 (lower is better)

ZigZag Segment 2

Duration 31.68 s, Accuracy Estimate 1.968 (lower is better)

ZigZag Segment 3

Duration 30.92 s, Accuracy Estimate 1.853 (lower is better)

ZigZag Segment 4

Duration 33.24 s, Accuracy Estimate 1.965 (lower is better)

ZigZag Segment 5

Duration 34.68 s, Accuracy Estimate 1.761 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 26.08
timePerZigzagCoV 0.0977091
timePerZigzagSlope -0.0538344
zigzagHeightMean 50.8782
zigzagHeightCoV 0.0394602
zigzagHeightSlope -0.0239909
meanError 0.0325197
tremorFreq 5.76172
tremorRelPower 22.6577
tremorGyroAmpMean 0.0203022
tremorGyroAmpSlope 0.000140187
tremorGyroAmpCoV 0.295387
tremorCoordAmpMean 0.0480794
tremorCoordAmpSlope 0.00169078
tremorCoordAmpCoV 0.308942
tremorAccAmpMean 0.0936841
tremorAccAmpSlope 0.000639511
tremorAccAmpCoV 0.0993954
tremorPcRelVar 0.660774
tremorPcX 0.257747
tremorPcY -0.966212

ZigZag Offset Segment 1

Duration 29.36 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 2

Duration 26.16 s, Accuracy Estimate 0.02 (lower is better)

ZigZag Offset Segment 3

Duration 26.24 s, Accuracy Estimate 0.021 (lower is better)

ZigZag Offset Segment 4

Duration 26.44 s, Accuracy Estimate 0.021 (lower is better)

ZigZag Offset Segment 5

Duration 22.2 s, Accuracy Estimate 0.067 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.65}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.19756129115794607}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Healthy’, ‘BM_HC_Sep22_score’: 0.054764408762993266}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.748213203110714}